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KMID : 0338420200350030703
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Korean Journal of Internal Medicine
2020 Volume.35 No. 3 p.703 ~ p.713
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Ten-year trends in antibiotic usage at a tertiary care hospital in Korea, 2004 to 2013
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Kim Bong-Young
Hwang Hyeon-Jun
Kim Ji-Eun
Lee Myoung-Jae
Pai Hyun-Joo
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Abstract
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Background/Aims: This study was performed to evaluate trends in antibiotic usage at a tertiary care hospital in Korea.
Methods: This study collated antibiotic prescription data and total patient days for inpatients at a tertiary care hospital in Korea between 2004 and 2013. The consumption of each class of antibiotic was converted to defined daily dose (DDD)/1,000 patient-days. We defined 3rd generation cephalosporins, 4th generation cephalosporins, β-lactam/β-lactamase inhibitors, and fluoroquinolones as broad-spectrum antibiotics; carbapenems, tigecycline, glycopeptides, oxazolidinone, and polymyxin were defined as antibiotics against multidrug-resistant (MDR) pathogens. Other antibiotic classes were defined as nonbroad-spectrum antibiotics.
Results: Mean antibiotic consumption was 920.69 DDD/1,000 patient-days. The proportions of broad-spectrum antibiotics, antibiotics against MDR pathogens, and nonbroad-spectrum antibiotics were 41.8% (384.48/920.69), 3.5% (32.24/920.69), and 54.7% (503.97/920.69), respectively. Consumption of broad-spectrum antibiotics (coefficient for time 0.141; p = 0.049) and antibiotics against MDR pathogens (coefficient for time 0.185; p < 0.001) showed a significant increasing trend over the study period. Nonbroad-spectrum antibiotic consumption showed a significant decreasing trend over the study period (coefficient for time ?2.601; p < 0.001).
Conclusions: Over the 10-year period, a stepwise increase in the consumption of broad-spectrum antibiotics and antibiotics against MDR pathogens was observed at a tertiary care hospital in Korea. Conversely, during the same period, non-broad-spectrum antibiotic consumption showed a significant decreasing trend.
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KEYWORD
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Anti-bacterial agents, Hospitals, Korea
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